Yes, if you have applications or games that are installed (Not portable executables) on another drive then you will probably need to format that drive as well and reinstall everything.
In some cases, like Steam folders, etc., you don't, so it's best to investigate on a case by case basis. If they are applications though, it's a pretty safe bet that they have deep roots in the registry and Windows folders even if they are primarily installed on another drive, and you'll need to reinstall them. Generally speaking I don't recommend installing applications on secondary drives. They should normally all be installed on the same partition as the operating system. Games, like Steam folders and such, are a different story and don't always need to be on the same drive. Some people tend to disagree on installing applications on the same drive but I don't see much reason to install them elsewhere as they always need to be reinstalled when you install a new or fresh copy of Windows anyhow, so unlike games that are mostly self contained, there is really no benefit to putting them on another drive UNLESS it is only due to space concerns and then I say well, you need a bigger drive then.