Crossfire hasn't seen any real support in any games since before the Rx580 was released, and even then it was pretty miserable, averaging 10% - 20% higher fps, at best.
Windows 10 natively supports mgpu through DX12, you'd need to use a DX11 title to get Crossfire to function, and results can vary from very little gain to actual negative impact.
Consider Crossfire and SLI as functionally Dead. There's a reason that only the 3090 still has an nvlink, all other 3000 series cards are devoid of sli ability.
As is, a 1650S and Rx580 are close enough in ability to be functionally the same thing. Win some/lose some. The 1650S wins more than the 580, but differences are game depending and not huge.
There's currently only 1 advantage right now to having ownership of those 2x Rx580's, the ability to put them up for sale on eBay and make a few $$. Other than that, there's no point in changing your pc to accommodate either or both.