What motherboard a CPU are you using?
Any intel cpu in the 1150, 1151, 1155, 1156 socket is going to run dual channel, even if you put 4 sticks in it will only run in a dual dual channel config.
intels 1366 socket could run triple, dual, and single channel
intels 2011-0, 2011-1, and 2011-v3 socket will do quad, triple, dual, and single channel
all AMD sockets from AM4 and older run in a dual/single channel config
AMD's TR4 socket run in quad channel mode.
For intel (1151) or amd (am4) i would go with just 2 sticks, it just plays nicer with the memory controller