dual channel is likely the only choice. single, dual/triple/ and quad channel memory is dictated by the CPU. I doubt your CPU supports quad.
4x8 is not quad channel.
dual channel refers to the memory controllers connection to the CPU. single channel is just that communications on a single line. dual channel has two lines from the memory to the CPU and unless you have a server/Threadripper quad channel with 4 lines from memory to CPU is not even an option.
quad channel is supported on very few machines. tri channel by very few machines. Dual has widespread support even on the lowest end CPU's
2 of your sticks will use one channel and the other 2 sticks will use the other channel. Dual channel is likely the only answer to your situation...