So in your typical computer the chassis is made out of metal. This is grounded. The power supply takes in three wires. Hot, Neutral, and Ground. Ground is for safety. If you touch the chassis you are effectively grounded. Since the chassis has much lower resistance then you do, any short circuits will take that path to ground.
When you insulate the components from the chassis, everything is 'floating' there may be a voltage on the system's ground plane and touching it could shock you.
Adding grounding wires or straps brings it closer to the intended design.
So lets say you install the standoffs on your acrylic, put the motherboard on top of that, before putting the motherboard screw in, add something like this to it :
https://images-na.ssl-images-amazon.com/images/I/41kEUjKx8ZL._SX355_.jpg
Now you can buy the loops and braid, or standard wire yourself, so you can neatly route them.
One end is now grounding the motherboard, run that to one of the screws on the power supply. The power supply is taking in the chassis ground in the three prong plug. So now there is no potential difference between the motherboard and power supply. The I/O shield will get grounded by the motherboard. The expansion cards are likely grounded through their connectors (graphics card). To be doubly safe, you might just take some aluminum tape and run that along where the screws would go in to hold them in place, and ground the last slot cover screw to the power supply as well. The front panel I/O will be covered by the connections to the motherboard, also low voltage anyway at that point.
Similar things SHOULD be done with the drives, but these days you don't actually have to have any with M.2 drives. But if you do end up with some drives, you could run a wire to a screw on their chassis.
Really though acrylic cases are neat to look at, but they do defeat one of the features of your typical case. They act as farraday cages to keep electronic interference both in and out of the chassis. Even the plastics on computer cases are usually embedded with conductive material to play the part of metal. (Same with laptops, the plastic is acting as shielding)