Ok. Here's my fans. 2x stock fans at intake, governed by MSI software from my motherboard. Cap on them at 100% duty cycle is 800rpm, low cap is 450rpm. 2x stock 140mm nzxt fans from the kraken x61 on top exhaust. Governed by Cam software through the cooler. That's it. No rear exhaust, no bottom exhaust, just 2x 140mm intakes and 2x 140mm exhaust.
Now because I use the radiator top Mount, I do loose the baffling that's stock there. It's trixy. Understand, a rear exhaust does nothing really to help top mounted fans. Any heat given from the gpu travels UP the side of the case, then out the top, cpu heat, out the top, case heat, out the top. Trying to force the exhaust 90° and out the rear is honestly pointless. Heat rises, gpu blows it up, fans blow it out. Simple. Natural progression. For me.
IF you decide on an air cooler (I'd suggest a cryorig R1, Phanteks ph-tc14PE or Noctua NH-D14), that changes everything. Those coolers draw huge amounts of air and direct it right at the rear exhaust. So. You could leave all the baffling on the top, run a single 140mm exhaust at elevated rpm and 2x 140mm intakes at reduced rpm. Vast majority of any gpu, case heat will naturally be directed to the rear, which won't be that loud realistically, the double intakes can spin slower and still provide ample cfm and the case is completely baffled. In this, it would be quieter than mine at full load since my exhaust is on top, so sound is right there vrs exhaust out back where sound is facing away.
Any of those big twin towers are capable of cooling @220w or better of thermal heat. Your cpu will be 100w or less, give or take, unless you OC. At stock or close to stock speeds, the overwhelming ability to transfer and dissipate heat of those coolers will mean they barely get warm. So their fans don't spin fast. Silent. Stock coolers are small, have barely adequate ability to transfer and dissipate heat. Get very hot. Fans spin really fast. Tons of noise. Oversized gpu is the same theory. If it's barely working, its not getting hot, so the fans (if you even need to turn them on) make no noise.
The only thing in a pc that really makes any noise is the fans. Find a way to slow them down, they get quieter. Anything under @900rpm is relatively quiet on average. Under @600rpm is inaudible. Pretty much.