If it is a very similar motherboard, same chipset etc... then you are probably ok with a reset.
If it is totally different. 2 or 3 generations or Intel to AMD a NEW fresh install is recommended.
Otherwise you will most likely have small random errors or performance issues that never go away.
Most will recommend a new windows install.
Easy for them, they do not need to do the work.
But, that will involve reinstalling apps(steam excepted) which might be difficult.
I would first protect yourself for whatever you cherish on the C drive.
Perhaps clone your C drive first.
Try to boot on the new motherboard and cpu.
If it will boot, install the new motherboard drivers and you will likely be ok.
You're better off reinstalling Windows for a mobo/cpu change. Whilst you may get by with not doing a fresh install, chances are you will be dealing with error messgaes, old drivers causing conflict among possibly more issues.
Whilst downloading steam game files might be annoying (you may have these on the HDD already though), it's a lot easier than trying to troubleshoot random issues caused by old drivers for hardware that isn't even there.