You need to find out if your MB has EUFI BIOS, or legacy AHCI. The video card must support it. My Sapphire R9-285 (same GPU) has Dual BIOS switch, so it can run old, or new BIOS. I'm running mine on an LGA775 QX6800 with out problems. I think R9-380 BIOS might be EUFI only. Not sure though. I don't know how Phenom compares though, some A10 are comparable though.