When I open Windows Explorer and right-click any given drive I have an option to run "Scan with Microsoft Defender....."
Selecting that immediately launches a scan on that drive.
If I cancel the scan then I get another window with four options:
Quick Scan
Full Scan
Custom Scan
Microsoft Defender Offline Scan
At the bottom is a "Scan now" button. I selected "Custom Scan", clicked "Scan now" and a window opened within which I could select what I wanted to scan.
Per
@mdd1963 - you will need to simply click and test to determine if the resulting choices and actions meet your requirements.