I've never worked with that particular "hot swap" bay (mobile rack), nor for that matter the ASUS MB you indicated. Ordinarily there's no particular problem with a mobile rack working with any reasonably modern MB. At rare times an installation problem may arise with the PC case for one reason or another, usually involving the case's 5 1/4" bay. However that's a very rare occurrence in our experience and generally there's no problem installing a mobile rack housing a 3 1/2" disk in any desktop PC's vacant 5 1/4" bay.
Over the years we've worked with a wide variety of mobile racks. I wouldn't build a desktop PC without at least one. We strongly advise any desktop PC user that whenever possible to install that device in their computer...