Depends which USB you use 3.0 , 3.1 or usb type-c .
Yes it will lose.
"USB 3.0 offers speeds of 5Gbps and 3.1 (generation 2) offers 10Gbps. Most SATA SSDs don't go over around 500MB/s which is about 4Gbps. USB 3.0 may limit some SSDs, but USB 3.1 (gen2) shouldn't. "