In my PC (Win 7 sp 1 pro 32 bit), I am getting the warning in event viewer every time on startup.
Windows detected your registry file is still in use by other applications or services. The file will be unloaded now. The applications or services that hold your registry file may not function properly afterwards.
DETAIL -
13 user registry handles leaked from \Registry\User\S-1-5-21-1130101045-2294661891-1522849317-1000:
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\My
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\CA
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Internet Explorer\Main\FeatureControl
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies\Microsoft\Internet Explorer\Main
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\Disallowed
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Internet Explorer\Main
Windows detected your registry file is still in use by other applications or services. The file will be unloaded now. The applications or services that hold your registry file may not function properly afterwards.
DETAIL -
13 user registry handles leaked from \Registry\User\S-1-5-21-1130101045-2294661891-1522849317-1000:
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\My
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\CA
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Internet Explorer\Main\FeatureControl
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies\Microsoft\Internet Explorer\Main
Process 616 (\Device\HarddiskVolume3\Windows\System32\lsass.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\SystemCertificates\Disallowed
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Policies\Microsoft\Windows\CurrentVersion\Internet Settings
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software
Process 1056 (\Device\HarddiskVolume3\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-1130101045-2294661891-1522849317-1000\Software\Microsoft\Internet Explorer\Main