They should have come up with a different title. The name already paints pictures of Native Americans fighting aliens, or bounty hunters in space and it doesn't offer any of that.
I bought the first Prey game because I had read about it in PC Gamer, but later confused the plot with Michael Crichton's "Prey". So confusion started long ago for me.
According to Wikipedia, this IS a sequel. Why it's called the same exact thing, Id o not know.