The build is compatible, all the parts will work together, the SATA issue is a common one and usually it doesn't effect ports 1 and 2, but, as Lucky_SLS says, just ignore the deactivated port, Windows won't care which ports you connect drives to and will assign drive letters to each connected drive as usual.
What content will you be creating and what software will you use?
What gaming will you do and what is the display you'll be gaming on?
In some cases a Ryzen build will offer a better all round solution providing: Your content creation software can fully use multiple cores and threads and you'll be gaming at 2K rez or higher; Intel is still king at high refresh HD gaming but the gap between them and AMD narrows significantly once you move beyond HD resolutions.
Your build with a few tiny tweaks:
PCPartPicker part list /
Price breakdown by merchant
CPU: Intel - Core i7-8700K 3.7GHz 6-Core Processor ($369.99 @ Amazon)
CPU Cooler: Noctua - NH-D14 65.0 CFM CPU Cooler ($74.95 @ Amazon)
Motherboard: Asus - Prime Z370-A ATX LGA1151 Motherboard ($158.90 @ OutletPC)
Memory: G.Skill - Trident Z RGB 32GB (2 x 16GB) DDR4-3200 Memory ($279.99 @ Newegg)
Storage: Samsung - 860 Evo 1TB 2.5" Solid State Drive ($166.89 @ OutletPC)
Storage: Toshiba - P300 3TB 3.5" 7200RPM Internal Hard Drive (Purchased For $76.89)
Video Card: Asus - GeForce RTX 2080 8GB ROG Strix Gaming OC Video Card ($899.99 @ B&H)
Case: Aerocool - P7-C0 ATX Mid Tower Case ($85.27 @ Amazon)
Power Supply: EVGA - SuperNOVA G3 650W 80+ Gold Certified Fully-Modular ATX Power Supply ($79.67 @ OutletPC)
Total: $2192.54
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2018-10-16 14:26 EDT-0400
Single SSD, cheaper, but still quality PSU BIG air cooler.
Note, unless you're after the very highest gaming or playing a very long game, you could swap the RTX2080 for a GTX1080Ti and save a significant amount of cash.