even thou you provided no useful info to answer your question (windows (what), mac, Linux?) you would gain no benefit anyway. Since all data loads from some type of hard disk. Disabling paging file or moving to another hard disk also gives you no benefit at all (unless u got like 30gig SSD and trying to squiz it) but that's space management not related to performance.
Windows 7 would load up most used stuff into ram anyway and leave it there,
Get fast SSD and RAM becomes even less useful i load huge programs off my SSD instant. and i got 32 GB of ram lol
Forcing stuff into ram = reading it off hard drive if its done at start up, you can actually have to wait at start up 5-10 minutes while it loads, witch is be backwards to faster start-ups. and if you after loading 5 mins try to play big game the windows will dump the ram contents and replace with game, and you end up where you started
And windows don't use Virtual memory if you have RAM space left, Programs will load ram then if it ends start virtual (hard drive)
There can be some use on start up, but its beneficial, since paging file is one big chunk, windows can load most used from it and not from 1000 places where it stored originally.
Get good SSD, or PCI express card SSD, and forget about ram!!!