It all depends on what you are doing. I had to abandon my C2Q as my main machine a long time ago because it simply choked on bandwidth when doing HD video editing and some games... But it still had a few years left over as my wife's main computer and was perfectly adequate for audio editing, office apps, light games, etc. I eventually replaced her system with an i3 Ivy Bridge setup due to a GPU failure and complaints of the C2Q being too loud in general... so now the C2Q is running as my home server, and will probably remain as my home server for a few years yet until it is a 10 year old chip (and 10GbE becomes more affordable).I am still using Core2 Quad Q9650. I can still bear it's power hungry character though... Until I see that there is a big advantage to upgrade, I will stay this way.
I want an mATX board with more fan headers, eSATA dual GLAN, everything, especially from AMD. Striped-down low-budget mATX motherboards, without a decent BIOS, are OEM specials that got away.... I'd really be interested in ATX boards under $100. For some reason, I can't stand the smaller form factor system boards.