Depends what your doing. Run ESXi and put all your VM's boot VHD's onto the IO-drive, *poof* instant boot-ability. If your spending that kind of cash then your not building a gaming rig, your building something for data processing.Why? it wouldn't have any improvement whatsoever.
PCI Express 2.0 x16 = 8 GB/s
this card = 6.7 GB/s
And all fusion io SSD's are all unbootable. OCZ, supertalent and photofast pci-e are all bootable.