I think it depends what you are going to use the machine for. If your gaming what games are you going to be playing. The FX-4130 is using the older core 125w running at 3.8Ghz, the FX-6300 is the newer core 95W 4.1GHZ. So if your playing a CPU intensive game the 2nd set-up is better. The GTX 660 is a faster GPU then the GTX 750, so it GPU performance is more important the 1st set-up is better. The AMD 260 and 265 if available in your area should be around the same price as the 750 and perform better.