Extra cost is obvious and expected for now. I believe the only CAMM2 on the open market currently is the LPCAMM2 from Crucial.
Isolated? Meaning there aren't many implementations? If so that's unfortunately to be expected due to the reality of manufacturing.
Lock-in implementations? what does this even mean? CAMM2 is a JEDEC specification which means any module adheres to that.
Reusability? What's the issue here exactly? They're no different than any other DRAM module specification.
Lack of standards? CAMM2 is a JEDEC standard so no:
https://www.jedec.org/news/pressreleases/jedec-publishes-new-camm2-memory-module-standard
There are technical standards and market stanards. Rambus was a technical standard, even saw adoption by Intel, but it failed to be come a market standard and made for expensive RAM that couldn't be recycled in a next generation system.
For me PC has always been about the ability to change and upgrade, reusing what was still good enough for reusing and I don't see CAMM2 getting the kind of traction that it would need to become a market standard.
The bandwidth limitations of dual channel RAM can't really be fixed with higher clocks, if you want more potent iGPUs (for graphics or compute) you need to go wider, perhaps much wider, as the fruity cult does or even Strix Halo, to a degree.
But that becomes expensive, even more so when you go off-chip or die carrier, double or quadruple RAM pins, and you need to accomodate amplifiers for longer traces, adding an extra chiplet in a matching node, die space, power, latencies: LP-CAMM2 may quickly cost as much as DIMMs in power and silicon real-estate, and would CPU vendors want to design just for LP-CAMM2 to optimize power?
How many RAM segments would the market support just within the laptop to desktop market, since most CPU SoC designs are shared among them? Sure, in theory Foveros would allow Lego RAM controllers, but that still needs scale to pay for the flexibility and Intel might no longer get there.
I'm pretty sure the temptation to just stick with soldered RAM and cover perhaps 90% of the market is too big, while a design that allows for everything from soldered to DIMMs doesn't give LP-CAMM2 much of a USP, just extra validation effort.
Current Strix Halo implementations seem to reflect that, each a lost LP-CAMM2 opportunity.
I'd love to be wrong, because I favor flexibility, but somehow PC vendors rarely give me exactly what I want, I guess because more value for me means less profit for them.