Does your $4000 budget include monitor/s??
If so, what do you have in mind?
Consider this carefully. A monitor will last a very long time.
If you are a fast twitch gamer, a fast tn panel will be good.
If you are more visually oriented, a ips panel with 178/178 viewing angle and better image quality will be better.
I would look for a largish 35-40" curved monitor for more immersive gaming.
Go see some candidates in person if you can.
Today, the top dog processor for whatever will be the i9-9900K.
It is in short supply and at early adopter prices. Still worth waiting for.
Most any Z390 motherboard will be fine. The more expensive ones will have premium sound and RGB "bling" if those are attractive to you.
I see no need for more than a 2 x 8gb ram kit. perhaps 3600 speed
On storage, buy a sufficiently large m.2 pcie ssd. A 1tb Samsung 970 evo is about $230.
If you play mostly few games, that will be sufficient.
You can always add more storage later. I would not go overboard on storage until you need it. ssd prices are dropping.
If you want to use a hard drive, look to wd.
A neat option for Z390 motherboards will be optane support.
You buy a 58gb m.2 optane drive and windows will use it as a cache for a large sata drive.
On graphics cards, the RTX2080ti is currently top dog.
If, in time that no longer does the job, there will likely be a faster single gpu card available.
I would not plan on sli.
Dual gpu has wonderful synthetic fps benchmarks, but is prone to stuttering and screen tearing.
An increasing number of games no longer support dual gpu.
Your gaming experience will be better with a good single graphics card.
Nothing wrong with overprovisioning a top quality psu.
750w is a good size, but nothing wrong with 850w.
It will only use the wattage demanded of it, regardless of the max capability.
Buy only a tier 1/2 unit from a quality list such as this:
https://linustechtips.com/main/topic/631048-psu-tier-list-updated/
Buy a case that visually appeals to you.
You will be looking at it for a long time.
Functionally, I have two criteria past the ability to hold my parts.
1. I want at least two 120/140mm front air intakes that are filtered.
You need good intake for any kind of decent cooling. A easy to remove washable filter will keep your pars clean.
2. I want at least 160mm available for a good air cooler like a noctua NH-D15s.
A air cooler will cool just as well as a aio cooler in a good case. It will be cheaper, easier to mount, run quieter, have no maintenance issues and will not leak.
Post a list of your prospective parts.