Valantar :
It has to be said: this board has a truly awful layout. That alone should be reason enough not to buy it. EPS connector squeezed in behind the rear IO, 24-pin, front IO and SATA all at the top of the board, and NOTHING at the front of the board? What were they thinking? Good luck fitting this in an SFF case with little room for cable routing around the top of the board.
Its not really that bad.... Gigabyte has had a very similar ITX layout for amd board(s) for a few years now and overall its layout is fairly ok from my experience. Think it all has to do with what case your putting the board in.
GA-F2A88XN-wifi itx board i've been running since 2015 in the RVZ01 case has essentially the same layout as this board and in this case, i can zip tie the front panel and usb cable alone side of the case with no problems. Only major down side to this layout is the sata cables (almost all 4 spots i can have drives in this case makes the cables run from one side of the case to the other).
24 pin location, i can see how it could affect in some cases but in my RVZ01, it the perfect length from the PSU to the connector and runs between the PSU bracket and motherboard, So it mostly blends in (Although the air cooler inside my case just hides it all anyways.)
Now the one thing that I do like about the layout from this board vs my board is the CPU socket is farther away from the memory and PCI-e slots which is a major plus as my board has very few large air coolers that'll work with both slots. (Coolermaster Geminii M4 is one of the few. Most of the popular one however block PCI-e or ram. So you cant use both.)
ESP connector location is a certainly a con as it has been moved up from by board and im not sure why... Made it real easy (in my case) to run the ESP cable near the motherboard (out of site in the GPU compartment) and just connect it right there. Now it farther up and you have a more visible cable running from the top or bottom of the board.
Dr Croubie :
Hopefully they'll bring out one without the wifi/bt, although at least that's on a riser card so it can presumably be unplugged by people who care about security.
It actually a vertical Mini PCI-e slot (the kind you find in laptops) that the wifi card is in and it is completely removable.
My board has a horizontal slot with the Intel AC 7260 half-height card and i can remove it and use it in another device (for the fun of it, I tried it in a old Pentium dual-core laptop (2008-ish) I had laying around with only wireless G in it and it fully works).