do I uninstall drivers? do I uninstall and reinstall all nvidia programs? They're both MSI (MSI 650 1GB OC to a MSI 660 2GB OC). Also will the EVGA 500w (100-W1-0500-KR) run the 660 fine?
1. Uninstall nvidia drivers from control panel and shut down
2. replace 650 with 660 (dont forget pcie plugs)
3. boot up and download latest driivers from nvidia website
4. Install and restart
Go ahead and try it. All Nvidia Geforce desktop GPUs since the 8000 series use the same driver. Worst case is it doesn't work and you just go to the Nvidia driver page and DL the one they link you to when you choose the 660. (click on "supported products" tab: http://www.nvidia.com/download/driverResults.aspx/75991/en-us)
To OP - your PSU is more than enough for the GTX660 as it reqrires a 450W PSU with 24A on the +12V rails and you have a 500W PSU with 40A on the +12V rails.
1. Uninstall nvidia drivers from control panel and shut down
2. replace 650 with 660 (dont forget pcie plugs)
3. boot up and download latest driivers from nvidia website
4. Install and restart