"Since we regular users don’t have this visibility into our software, we might end up being the hardest hit by the Meltdown/Spectre fixes."
There have been a number of tests that show desktop performance will not be affected significantly. In doing some tests, the biggest difference in one test for a heavy Photoshop load only amounted to a tenth of a second difference. So almost all desktop users won't see much of a difference.
However, the biggest hit is in all those disk benchmarks. In their synthetic tests, they are seeing 30-40% drops. Now that is going to be interesting to see how they figure out how to get accurate results. I feel a little sorry for the ones doing those benchmarks; perhaps they will need to keep an unpatched system (non-Internet connected, of course) to keep running them for a while.