There absolutely will be a difference. If you have a good, name brand TV, the upscaler on the TV will be much better than that of the video card (at least currently, hopefully video cards will improve on this in the future). On no-name TVs, the video card upscaler will be a bit better. I've witnessed this myself with multiple 4k displays. The quality of TV brand makes all the difference. You should be just fine with Sony. As for another answer suggesting that setting your output to 4k will restrict your refresh rate to 30hz, that is not correct. HDMI 2.0 made 4k 60hz a standard for the interface and both your video card and TV are HDMI 2.0 compliant. Also, don't worry about your desktop/icons at 4k, you can use the Windows...