https://www.youtube.com/watch?v=qWj0ozJCZuo
Long story short is there seems to be no reason to use MCE (Multicore Enhancement). The CPU should stay at 3.8GHz on all six cores loaded which is fine.
I'd just concentrate on getting a 3000MHz or 3200MHz DDR4 memory kit (2x8GB) such as Corsair LPX or whatever, then use "XMP" in the BIOS.
Install the motherboard FAN SOFTWARE, tweak the fan profile so you stay below 80degC under heavy load and you should be good. So...
1) First, update the BIOS
2) set "XMP"
3) run MEMTEST86 for a full pass www.memtest86.com
4) attach SSD/HDD's
5) Install Windows 10 64-bit, drivers etc.
FYI, if you aren't aware, you should have your Windows E-mail + Password that you plan to use (i.e. MSN account) ready so you can type it in during Install.