GTX 650 and Amd Apu

Solution
There is no compatibility issue between a CPU and a GPU. Make sure you have enough wattage and PCI-E connectors to handle the new GPU. In addition, make sure the case will fit the GPU.

it will be much better in most games, some CPU heavy games like strategy games or online MMO may still be a little on the slow side (but not slideshow lol) but action games, fps and racing games for example will be a lot better. have fun!