O-rings on the tube fittings have failed on me before, just a simple replacement job (old H80i I had). The main seal though is more tricky, but still replaceable with gasket material. If it is still pliable and not cracked it should be re-useable, just clean it without too much force. If a whole bunch of black gunk comes off when wiping it repeatedly, it needs replacing.
If you completely clean it, refill it with distilled water and a biocide, and the pump still spins, maybe. (Or coolant if you ever expect it to be exposed to freezing temperatures)
Priming the pump is the tricky part since the only 'fill' location is the pump block itself. It is usually necessary to pop the tubes off, completely fill the tubes and radiator before attempting to turn it on. Once it is working, you pretty much have to take it apart again to top it off with fluid.
You would want to test it once reassembled, and monitor it closely.
So if that sounds like something you want to do rather than spending $60-80 on a replacement, it can be a fun afternoon.