G
You'll need more anti-spyware programs than just Spybot. Add Ad-Aware SE, and I'd add either M$ Anti-Spyware or a paid program. Spybot misses a lot and SpywareBlaster only sets killbits for IE. I use Spy Sweeper (as a scaner only), Pest Patrol (free thru my ISP) and CounterSpy (I got a comp copy).
Spyware seems to be a bigger problem now than viruses. A decent AV (Avast is good) and a free fire-wall (Zone Alarm) works.