Depends which M.2 you use. The first M.2 is used it removes the SATA 5/6 support. The other slot changes the PCIE slot from x16 to x8 however that makes little difference in gaming performance (2-3 FPS max). The manual, from what I've seen doesn't specify which M.2 is which but I'd assume the one on top is one and the one on the bottom is two.Does that cause a problem or slow performance?
It causes two of the sata ports on your motherboard to just stop working completely. I had to use the other 4 for my hard drive and ssdDoes that cause a problem or slow performance?