from adaptec:
http://ask.adaptec.com/app/answers/detail/a_id/17242/~/are-4tb-drives-supported-on-adaptec-controllers%3F
Support for 4TB drives is available on the following controllers:
Series 8 (8805, 8885, 8885Q, 81605ZQ)
Series 7 (7805, 7805Q, 71605E, 71605, 71605Q, 78165, 71685, 72405)
Series 7H and 6H (71605H, 70165H, 7805H, 7085H, 71605He, 70165He, 6805H, 6405H)
Series 6, 6E, 6Q, and 6T (6405, 6445, 6805, 6405E, 6805E, 6405T, 6805T, 6805Q, 6805TQ)
Series 2 (2405, 2045, 2805, 2405Q): using firmware/BIOS version 5.2.0 Build 17911 (or later)
Series 5 (5405, 5445, 5805, 5805Q, 5085, 51245, 51645, 52445): using firmware/BIOS version 5.2.0 Build 17911 (or later)
Series 5Z (5405Z, 5445Z, 5805Z, 5805ZQ): using firmware/BIOS version 5.2.0 Build 17911 (or later)
Series 3 (3405, 3805, 3085, 31205, 31605): using firmware/BIOS version 5.2.0 Build 17335 (or later)
SATA II HostRAID 1220SA, 1420SA, 1430SA: using firmware/BIOS version 6.0-0 Build 2507 (or later)
All other controllers cannot use 4TB disk drives.