True it messes things up but that can be overcome with discrete video cards, sound card and running the hdd in ide mode. I disabled the igp, onboard sound, 1384a, serial port. That sounds bad but then if you can gain a extra 960MMZ, it becomes well worth it.
It depends on what board, cpu and brand. AMD's tend to overclock fairly well with this, some intel cpus do not, like the sandybridge, ivy.
I have a A6-3650 Llano apu. Stock is 2.6ghz. I have mine running at 3.56ghz, kingston hyperx blue 4gb kit 2x2gb ddr3-1600@1826mhz, ht bus, pcie bus and memory, all overclock with the fsb (BCLK). stock fsb (BCLK) is 100mhz and mine is 137mhz. So that would be a 37% BLCK overclock.
It's running with a pair of HD-7850's and a x-fi Fatl1ty sound card on a micro atx gigabyte GA-A75M-UD2H.
It varies from boards and cpus how much you can go up. The board i have is one of the socket FM2 boards that is known to overclock well. It depends on your memory and board too. I set mine at 1600 timings and manually set it at 1333 and ends up at 1826.