If you are only using HDMI the yes it should. At least all of the GPU's I have used had no problem with HDMI being the only video out. I had full video out for the POST and BIOS and such no problem. For audio to be sent though the HDMI you would need to right click on the speaker icon in the task bar and select Playback Devices. From there you will need to find the correct HDMI out option and select that as default. After that you should have HDMI audio out to the TV.