modern graphics card are typically dual slot, with some specialty low profile cards being 1 slot. Some cards with after market cooling may be 2.5 slot or even 3 slot. Since you are planning on a 4 way SLI set up, which is a pretty niche build. I would suggest you look at the specific cards you plan on using and determining if your case/mobo/psu can support them. If the card you want is 2 slot, you are likely fine, if its 2.5 slot, you might have an issue. But there is no point in speaking in generalities for something like this, you should list the specific parts you plan on using.