spyguy :
Lets say on a 1tb hard drive for example. When would the limited space begin to slow performance?
90% is when you will notice the slowing of processes. Keeping below this and not staying near it is recommended.
If you have the funds, I highly recommend a SATA SSD or an M.2 SSD for your OS & OS pertinent programs while having an HDD for mass storage, including games. A SATA SSD can speed up performance by about 2.5 to 3 times on average.