Although I just use Virtual Box to create virtual machines of various distros, its nice to see a well made tool to enjoy a native experience of booting a linux distro from usb. Hopefully with Nvidia (and hopefully followed by AMD and Intel) loosening the walled garden of gpu passthrough in virtual machines, we are slowly approaching a moment when we can truly have unlimited freedom on what os (or os distro) we want to run with the only restriction being dictated by the performance of the hardware components and quality of the drivers.
You can use a persistence file with most Linux distributions too to preserve your settings without needing to install, very convenient for a portable troubleshooting tool to use on multiple computers.