I've recently tested installation on USB thumb drive.
The experiences lead to this conclusion
- Important : The guide never mention this, Any storage device that is not a part of installation (boot media and the storage device you plan to install OS onto) should be disabled from bios menu, so that you don't take the risk of destroying the existing system.
- If choosing just a regular USB thumb drive (even usb3), you'll ending up with a very slow system.
- I'd recommend a more light distro. For this purpose, MX Linux works well.
- There are OS out there that are specific made to be run from a usb thumb drive, such as Nomad BSD. However, from my own experience, there is not that much gain choosing Nomad BSD over a light Linux distro.
- Some or several distros may not successfully load after installation - in my case I tried to install Fedora 33 and it wasn't able to load (stuck forever until forced power off).
My test was on a Corsair Flash Voyager GT usb 3.0 64GB.
[edit]
Also have to add (after reading
itsdigger post below) : The test I mentioned was to do a regular install, i.e. not persistent USB drive.