Of course! I didn't add any rear vents because, with the lid cooling the CPU and GPU (by the company's own flexible-tube heatpipe design) I wanted all the air to move through the front and out the PSU. This design would be ideal for a PSU with 120mm fan, the mounting holes are alligned for facing the fan upwards where it pulls air down into it. This is all about low noise and adequate cooling, remove the CPU and GPU heat from the inside and you don't need as much fan.
Both upper drives clear all cards. That means you can put a 7800GTX in the top slot and still have it clear the left-side DVD device.
I thought it might be interesting to suggest the company include four small feet to sit between the fins for stacking things above the case.
The buttons are for adding a device to duplicate remote fuctions. The front panel extrusion is designed to hold screws, for putting a PCB behind the buttons. Since I didnt' design the actual electronics to support that function, I can only make suggestions as to which remote control functions they should replicate.