Also, you surely know how hard it is to learn even a fraction of what some of these popular LLMs know. And that's using your whole human brain. There's no way an organoid is going to learn data on the scale of what LLMs deal with.
I think we'll end up seeing brain-computer hybrid technology to get the best of both worlds, IF literal biology is going to play any significant role at all in future computing/AI. Organoids could also be run in parallel with fast interconnects.
Brain-inspired neuromorphic computing can also be a lot more efficient than AI-focused GPUs. But it won't die if you don't give it nutrients on schedule.
We haven't even scratched the surface of what's possible, because unlike organoids, we don't have massively multi-layered monolithic 3D chips, neuromorphic or otherwise (if the neuron-like elements use infrequent spikes like neurons, that lowers power consumption and heat, which is one of the biggest issues with 3D).
I question how using human brain tissue is ethical?
https://en.wikipedia.org/wiki/Cerebral_organoid
Brain organoids are permitted in part because they are small and simple, avoiding the ethics issues. You have to wonder if connecting them in parallel or some other tricks could increase their capabilities.
I've heard 1 year for survival but they may have extended that.