That card can't utilize PCIx 2.0 much less the bandwidth of 3.0. So no worry there. The difference between 1333mhz and 1600mhzl; negligible. If you're going to overclock that chip though; I would switch out. And if you're going to switch out, hit the Z77 up for sure and don't fall back to a P67 just to save a dollar or two. The Z77 is an Ivy Bridge chipset and matched with the Ivy Bridge processor provides that PCIx 3.0. However, paired with the Sandy Bridge like you have with the gear you have; it's not worth upgrading to an Ivy Bridge CPU. So I guess it depends on if you want to spend the money on a Z77 board just to have the ability to overclock. The increase in memory speed is just an added little bonus.