You can use manual but that will force your set voltage running 24/7. I am using Offset instead that allows voltage fluctuation based on load. Offset is more difficult for high overclocks but for 4.1 you are going to make it easily. Start by small increment of plus +0.01 until you are stable. I cannot tell the exact voltage required since every chip will overclock in a different way but most probably you can be stable at 4.1 with 1.2 or 1.21 volts, since it's a mild overclock. It;s gonna be trial and error thing. 20 mins of Prime are not sufficient. Recommended is you run it over night.
Overclocking can be very time consuming for someone who is not experienced, and very fun for an experienced one. Take your time until you find the...