"programs I have installed and running are bitdefender, msi afterburner, real temp, asus gpu tweak 2, and msi command centre"
Keep bit defender, uninstall or disable the junk-ware and overclock in the BIOS/UEFI if needed. If you just disable instead of uninstalling these then please ensure that, not even 1 process from these is running.
msi afterburner
real temp
asus gpu tweak 2
msi command centre
So is it an MSI card or an ASUS card?
I have an EVGA card... You know how many GPU management utilities I have installed along with my video card? NONE
Drivers make it work, everything else will slow you down. Overclock in the UEFI if needed.
Be an extreme minimalist when it comes to your PC, it will keep you from getting stuck with a poorly programmed, boat anchor software that thinks it should take over every aspect of your PC.
I also suggest a full virus/malware scan. I still don't think you're going to find any hardware issue.
It's probably one of those programs you have running in the background checking for or downloading an update.