I don't know about the rest of it yet, but as far as the cooling is concerned, I'd start by switching your thermal readings to celcius. Nobody really uses fahrenheit and it's just liable to cause confusion anytime you ask for help.
As to the positive pressure, if your case does not have intake filtration then it might be somewhat helpful, to some degree, in combating dust from entering the system, BUT, it is far more stressful on your intake fan motors and bearings and cooling performance is reduced in an almost directly linear scale depending on how far the system leans towards the positive pressure side of the scale.
Negative pressure on the other hand always cools better. Bringing more air into the case is not particularly beneficial if you cannot get the already heated air out of the case faster than you are bringing it in. A balanced approach that may lean slightly to one side or the other but is mostly symmetrical is really fine. I doubt that case cooling is your problem however. Even with your configuration you have enough airflow that heat is unlikely to be the cause of your woes unless we are not getting an accurate depiction of your thermal status.
I would recommend starting with a semi-clean slate by doing a clean install of the graphics card drivers. Often, when there has been multiple driver installations, especially if any previous driver version had issues or was buggy, there can be problems later on. Even when no such issues existed, layered installations can still become problematic. The issue could also simply be, and often is, a windows issue rather than anything related to the actual driver package or version.
Try this first and then we can move forward if it fails to help. Even if you HAVE previously used the DDU in the past, do it again, and be sure to start the DDU installation in safe mode by holding the shift button down while you click restart and then start the DDU after Windows has restarted in safe mode. In the past the DDU would automatically restart the system in safe mode but apparently that has been removed in recent versions. Running the DDU without being in safe mode can result in some problematic files or settings not being removed, which then leaves you exactly where you already are.
How to boot to safe mode in Windows 10:
https://www.digitalcitizen.life/4-ways-boot-safe-mode-windows-10
GPU card clean driver installation:
http://www.tomshardware.com/faq/id-2767677/perform-clean-install-video-card-drivers.html
Also, knowing your FULL system specifications would be helpful, particularly your memory and storage configurations.