Nope, not at all. In Crossfire or Sli, you have two or three or possibly 4 cards. In a nutshell, one card is the master and the others are slaves. You connect your monitor to the master card which is usually in the first PCI-E slot on your motherboard. One correct cable per monitor, so if you have say two monitors, you would need one cable for one and another cable for the other and both cables get plugged into the Top Master