katalyst12 :
These are the main framerate killers in Witcher 3. Dropping them down a bit should have a big impact.
Turn Hairworks off
Turn Foliage Visibility Range from Ultra down to High
Set shadows to high or medium
Lower Ambient Occlusion
Turns out that's where I already had stuff. Should I turn it down further, seems the 780 can't do it
EDIT: turned hair works and related settings off (like Tress FX it kills my frames)
turned water quality dwn to high
ambient occlusion to ssao+
sharpening to low
and am now at 57 fps
one or two settings caused a massive improvement. i can't remember which ones though