The only time I'd be worried at ALL about having positive pressure, is if you're in a room where dust or dirt are prevalent, and you have an older case without filtration. If it's a fairly dust free environment (Yes, there are NO fully dust free environments in the average home, but there are certainly varying levels) or you have filtration on your case, you absolutely want a negative pressure system if cooling performance is more important than dust suppression. Even with a positive pressure system, there will still be dust, just not as much.
A cheap air compressor or a few cans of compressed air, to be used every month or two, makes this a moot point anyhow.
Negative pressure systems can result in as much as a 15°C internal case...