It can support an i5-3570k but it will not support overclocking the CPU. It will not support multiple GPUs because it only has one PCIe x16 slot. Honestly, don't bother with an Intel-branded motherboard. Look for an Asus, ASRock, MSI, Gigabyte, etc based on the Z77 chipset. If you want to OC then AT LEAST get a board with heatsinks on the VRM and 8+ power phases for the CPU. And if you want multiple GPUs make sure it has at LEAST 2 PCIe x16 slots running at x8, x8 speeds. ASRock's Extreme4 is a good example: http://www.newegg.com/Product/Product.aspx?Item=N82E16813157293