Unless you *need* the small size and low power consumption, it's generally not worth it. You can usually put together a full desktop with equivalent specs for 2/3 to 1/2 the price.
Usually it's people who want to mount it behind a TV as a HTPC that go for this form factor. Most people wanting portability and low power consumption get a laptop instead. (In fact I frequently recommend laptops instead of a NUC as a HTPC - they're a lot cheaper and easier to find used on Craigslist or eBay, especially if the screen is busted.)