Well, then, so much for all our deep thoughts about W2K!
First thing to try, disable "Plug and Play OS" in the BIOS. At the same time, be sure to set "Clear Configuration Cache on next boot" to "Yes" so that the BIOS will erase any previous configurations it may have stored. I assume that you have the usual IRQs available and not assigned to legacy devices, i.e. IRQs 11, 10, and 5 are usually available. If you need more than three, disable an unused legacy device (I disabled COM2 to free up IRQ 3), also in the BIOS. Some mobos may allow you to manually assign IRQs at the BIOS level based on the slots your cards are in; you may or may not want to do this (don't know what system you have). When you're satisfied with the BIOS config, bring it back up in ME and see what you get after the BIOS changes. This will probably shuffle things around, though you still might not be happy with the result and may need to reseat some cards to separate certain devices that still seem to be paired. On my system, this occurred initially because I had filled the AGP and then put cards into the PCI slots in sequence. Because of the way my mobo is wired for hardware interrupts, this forced the AGP card to share an interrupt with one of the cards that I had in slots 1 and 2 (I have the A7V133). I corrected this problem by leaving slot 1 blank and moving that card to slot 3.