Depends on the resolution.
Right now, I think most people will say that although 1GB is adequate for up to 1920x1200 resolution, 2GB of VRAM is preferred. For 2560x1440 to 2560x1600, 2GB is adequate, but at least 3GB is preferred. For a triple monitor setup with 5760x1080 resolution you will want 4GB.
Having beyond 4GB of VRAM on a single graphics card for 5760x1080 seems to be a waste of money the last time I looked at benchmark results between SLI'ed GTX 690 w/ 4GB and SLI'ed GTX 690 w/ 6GB. I was helping out someone in the UK over the summer who was asking if the extra $150 (USD) for each GTX 690 (a total of $300 USD), was worth the money. The benchmark results I've found was that at best the increase in performance was 3 FPS, but...