If you're taking the side panel off entirely, then you shouldn't have anything to worry about at all. At work here, half the time we use paper towels, but if there is dust on the parts, etc then used canned air and tilt your system (SAFELY) to help blow the dust and debris out. If you need more tips, check out this short "how to" with some good tips. http://www.webopedia.com/quick_ref/cleaning_computer_devices.asp